The U.S. National Science Foundation has renewed its support for the Molecule Maker Lab Institute (MMLI) at the University of Illinois Urbana-Champaign with a new five-year, $15 million award. As a National AI Research Institute, MMLI is pioneering artificial intelligence tools that accelerate the discovery and synthesis of functional molecules for use in medicine, energy, and industry. Led by Professor Huimin Zhao, the institute has already produced impactful innovations like AlphaSynthesis and closed-loop molecule development systems, and it now aims to develop next-generation AI agents, including large language models for chemistry and generative tools for catalyst discovery.