Nearly 80 participants including our members, industrial partners, and other researchers from academia and industry joined us in-person and online for the MMLI Symposium 2025, held April 15–16 in the Auditorium of the NCSA at the University of Illinois in Urbana, Illinois. Centered on the theme “AI Scientists? What Would It Take?”, the event featured talks and panel discussions from academic, industry, and national lab researchers. Sessions explored foundational AI, small molecule discovery, and materials development, highlighting emerging opportunities at the frontier of AI-driven science. Recorded talks and event photos are now available.